15 Disturbing Consequences of Sugar

September 18, 2016

People have been sounding warnings about the dangers of too much sugar for a long time. As early as 1957, John Yudkin, a professor of nutrition at Queen Elizabeth College in London, began arguing that when it came to heart disease and other chronic ailments, sugar — not fat — was the primary culprit.

Yet decades ago, after a landmark study by a team of Harvard scientists pointed to fat as the primary dietary risk factor for heart disease, Yudkin’s hypothesis was buried, and fat became public enemy No. 1.

Now it turns out that the sugar industry deliberately engineered that groundbreaking study, compensating the scientists for their efforts that essentially let sugar off the hook. That’s the conclusion of a September 12 report in JAMA Internal Medicine, which summarized an analysis of historical industry documents.

Even before that eye-opening report, however, evidence documenting the ill effects of too much sugar has continued to pile up. The Food and Drug Administration (FDA) says people should cap consumption at 50 grams of sugar a day — about 4 tablespoons or a little more than a can of Coke. The World Health Organization (WHO), meanwhile, suggests no more than half that amount for best results.

Yet the average American, trained to be wary of fat, gobbles up 22 teaspoons of sugar per day. And now we can say for sure: We should never have abandoned a diet rich in healthy fats, and all that sugar we’re eating instead is associated with a litany of health problems — just as Yudkin suggested all those decades ago.

Keep scrolling to see the potential consequences of eating too much sugar, according to the latest scientific research.


Trust your dentist on this one: Of all of sugar’s potential ills, the connection between sugar and cavities is perhaps the best established. Sugar is such an enemy to dental health that one study back in 1967 called it the “arch criminal” behind cavities.

Dentists have since called for much stricter limits on sugar intake than even most dietary guidelines advise.

“Tooth decay occurs when the bacteria that line the teeth feed on simple sugars, creating acid that destroys enamel,” Anahad O’Connor explains at The New York Times. Sour candies, which create more acid than other candy, are especially nefarious for causing cavities.

Insatiable hunger.

The hormone leptin tells your body when you’ve had enough to eat. In people who develop leptin resistance, this “I’m full” signal is never received, presenting a major obstacle for weight control.

A few studies raise the possibility that leptin resistance may be a side effect of obesity, not a contributing cause. But research in rats suggests that over-consumption of fructose — as in high-fructose corn syrup, which is common in soda — can directly lead to higher-than-normal levels of leptin and reduce your body’s sensitivity to the hormone. (Removing fructose from the rats’ diets generally reversed those effects.)

“Our data indicate that … fructose-induced leptin resistance accelerates high-fat induced obesity,” concluded one study of rats. And high levels of leptin may actually be an early warning sign of the larger metabolic problems associated with drinking too much soda, a 2014 study found.

More research is needed to confirm sugar’s connection to a bottomless appetite, but the results so far are worrisome.

Weight gain.

Other than adopting a completely sedentary lifestyle, few ways of packing on the pounds work as swiftly and assuredly as making sugar a staple of your diet.

Sugary foods are full of calories but do little to satisfy hunger. When researchers studied the eating habits of a large group of Japanese men, for example, they found “a significant association between sugar intake and weight gain” that held even after they accounted for other things like “age, body mass index (BMI), total [caloric] intake, alcohol, smoking and regular physical exercise.”

That squares with a huge body of research on the subject. A 2013 review of 68 different studies found “consistent evidence that increasing or decreasing intake of dietary sugars from current levels of intake is associated with corresponding changes in body weight in adults.”

Want to lose weight? Cutting your sugar intake is one of the best places to start.

Insulin resistance.

When you eat a lot of high-sugar meals — donuts for breakfast, anyone? — it can increase your body’s demand for insulin, a hormone that helps your body convert food into usable energy. But when insulin levels remain high, your body becomes less sensitive to the hormone, and glucose builds up in the blood.

Scientists can quickly induce insulin-resistance in rats by feeding them diets that are abnormally high in sugar.

Symptoms of insulin resistance can include fatigue, hunger, brain fog, and high blood pressure. It’s also associated with extra weight around your midsection. Still, most people don’t realize they’re insulin-resistant until they develop full-blown diabetes — a much more serious diagnosis.


Between 1988 and 2008, the prevalence of diabetes in America increased by 128%. Today diabetes affects about 25 million people in the US — or 8.3% of the population. Countries with higher sugar intake face higher rates of diabetes.

One study that followed 51,603 women between 1991 and 1999 found an increased risk of diabetes among those who consumed more sugar-sweetened beverages — including soda, sweetened ice tea, energy drinks, etc. And a massive review of prior studies involving 310,819 participants supported the same result, concluding that drinking lots of soda was associated not just with weight gain but with the development of type 2 diabetes.

The American Diabetes Association, while it recommends that people avoid soda and sports drinks, is quick to point out that diabetes is a complex disease, and there’s not enough evidence to say that eating sugar is the direct cause. But both weight gain and sugary drinks are associated with a heightened risk.

Portions seem to be crucial when it comes to sugar and diabetes. A 2013 study of eating habits and diabetes prevalence in 175 countries concluded the following: “Duration and degree of sugar exposure correlated significantly with diabetes prevalence … while declines in sugar exposure correlated with significant subsequent declines in diabetes rates” — even after controlling for other social, economic, and dietary factors.


Obesity is one of the most-cited risks of excess sugar consumption. Just one can of soda each day could lead to 15 pounds of weight gain in a single year, and each can of soda increases the odds of becoming obese, a JAMA study noted.

While it’s possible that drinking soda is harmful — above and beyond other sugary foods — the relationship is complex: If people who drink soda don’t consume more calories overall, that might not hold true. But too many “empty” calories often leads to over-consumption in general.

Sugar might directly raise the risk of obesity, but the association could be tied to diabetes, metabolic syndrome, or habits (e.g. diet and exercise) associated with high-sugar diets.

“The complexity of our food supply and of dietary intake behavior, and how diet relates to other behaviors, makes the acquisition of clear and consistent scientific data on … obesity risk especially elusive,” concluded one review.

But a more recent study cautioned, “we should avoid the trap of waiting for absolute proof before allowing public health action to be taken.”

Liver failure.

High doses of sugar can make the liver go into overdrive: The way our bodies metabolize fructose can stress out and inflame the organ. That’s one reason excess fructose is called a “key player” in the development of nonalcoholic fatty liver disease, where fat accumulates throughout the liver.

People with this diagnosis usually drink two times more soda than the average person. Still, the research is “unresolved” on whether sugar specifically is a culprit, or if it’s the weight gain that typically comes with eating too much sugar.

Most people with nonalcoholic fatty liver disease see few complications and often don’t realize they have it. But in some people, the accumulated fat can lead to scarring in the liver and eventually progress to liver failure.

Pancreatic cancer.

Some studies have linked high-sugar diets with a slightly elevated risk of pancreatic cancer — one of the deadliest forms of the disease. The link may be because high-sugar diets are associated with obesity and diabetes, both of which increase the likelihood someone will develop pancreatic cancer.

At least one large study, published in the International Journal of Cancer, disputed the link between increased sugar intake and increased cancer risk, so more research is needed.

Kidney disease.

The idea that a high-sugar diet — and too much soda in particular — may be a risk factor for kidney disease is still just a hypothesis, but there’s some reason for concern.

“Findings suggest that sugary soda consumption may be associated with kidney damage,” concluded one study of 9,358 adults. (The association emerged only in those drinking two or more sodas a day.) And in 2014, a large analysis of previous research on the topic supported the same finding, suggesting a strong association between drinking too much soda and developing kidney disease.

We also know a little more through highly controlled studies of rats. Rats fed extremely high-sugar diets — equivalent to 12 times the sugar in the WHO’s guidelines — developed enlarged kidneys and poor kidney function.

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