Failed GM Mosquito Control Experiment Backfires

September 14, 2019

When they fumble with Mother Nature, what can possibly go wrong….

Mosquitoes are more than just a pest – they can be downright dangerous carriers of disease. One of the most innovative ideas to control populations of the bugs has been to release genetically modified male mosquitoes that produce unviable offspring. But unfortunately a test of this in Brazil appears to have failed, with genes from the mutant mosquitoes now mixing with the native population.

The idea sounded solid. Male Aedes aegypti mosquitoes were genetically engineered to have a dominant lethal gene. When they mated with wild female mozzies, this gene would drastically cut down the number of offspring they produced, and the few that were born should be too weak to survive long.

Ultimately, this program should cut down the population of mosquitoes in an area – up to 85 percent, in some early tests. This of course means fewer bug-borne diseases, such as dengue, yellow fever, zika, and malaria, in humans. And since the offspring don’t live long enough to breed themselves, genes from the engineered bugs should stay neatly out of the gene pool of the wild population. The only visible effect should be the reduction of mosquito populations.

Unfortunately, that hasn’t been the case. Researchers from Yale University have now examined mosquitoes around the city of Jacobina, Brazil, where the largest test of this technique has taken place over the last few years. Not only did numbers bounce back up in the months after the test, but some of the native bugs, they found, had retained genes from the engineered mosquitoes.

“The claim was that genes from the release strain would not get into the general population because offspring would die,’’ says Jeffrey Powell, senior author of a study describing the discovery. “That obviously was not what happened.”

The GM mosquito strain was developed by a company called Oxitec, and it had previously been given FDA approval for these kinds of tests. In the Brazilian case, around 450,000 modified males were released in Jacobina every week for 27 months, totaling tens of millions of bugs. To keep tabs on them, the Yale team studied the genomes of both the GM strain and the wild species before the release, then again six, 12 and 27 to 30 months after the release began.

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