Lockdowns Put Kids at Risk of Allergies, Asthma, Autoimmune Diseases

April 2, 2021

“Eat dirt!” is a phrase I remember well. It was in the title of an article published by Harvard University environmental health professor, Dr. Scott T. Weiss, and it captured my attention while I was learning about an immunological concept known as the “hygiene hypothesis.”

The core of the idea is that we live in a microbial world: an environment full of bacteria, parasites, viruses, and fungi. And that our interactions with these microbes after birth are extremely important to educate our immune systems to function properly. When we are born, our immune systems are still maturing.

I like the way researchers led by microbiologist Sally F. Bloomfield expressed it in their study:

“The immune system is a learning device, and at birth it resembles a computer with hardware and software but little data. Additional data must be supplied during the first years of life, through contact with micro-organisms from other humans and the natural environment.”

The immune system has many potent mechanisms for killing pathogens. It needs to be carefully regulated to ensure it can eliminate dangerous microbes from the body without causing excessive harm to our own tissues. The interactions we have with our environment early in life are essential for our immune systems to learn to differentiate between safe and dangerous disease-causing microbes.

Our bodies are covered inside and out with micro-organisms that, under normal circumstances, happily cohabitate with us and promote a healthy immune system. If infants, toddlers, and young children aren’t sufficiently exposed to the microbial world around them, their ability to properly regulate their own immune systems can be compromised.

To return to the computer analogy, the data that gets uploaded into the software is incomplete. This lack of data can cause the immune system to struggle to differentiate between what is truly dangerous and should be eliminated, and what isn’t dangerous and shouldn’t be responded to. In plain terms, this scenario can promote allergiesasthma, and autoimmune diseases.

Concrete Jungles

Scientists are moving away from using the term “hygiene hypothesis” because it could be misinterpreted as meaning that hygiene isn’t good for a developing immune system. This isn’t true, nor should anybody advocate for actually eating dirt to gain exposure to microbes. Moderation and targeted hygiene would be best.

Societies have also adopted behaviors that limit exposure to microbes. The overuse of antibiotics exacerbates the problem by non-discriminately eliminating good microbes along with bad ones. Specifically, we need to practice proper hygiene in the context of trying to prevent infectious diseases but still allow our immune systems to interact with safe and essential microbes.

Many middle-income countries have seen an epidemic of allergic diseases over the past several decades. This is, in part, due to increased urbanization which is akin to living in “concrete jungles” with reduced exposure to the natural environment.

Bloomfield and her team of microbiology researchers provide some suggestions for how to deal with the rise in allergies.

Evidence suggests a combination of strategies, including natural childbirth, breast-feeding, increased social exposure through sport, other outdoor activities, less time spent indoors, diet and appropriate antibiotic use, may help restore the microbiome and perhaps reduce risks of allergic disease,” they advise.

“Preventive efforts must focus on early life.”

Now think about government-led responses to COVID-19, which was declared a pandemic by the World Health Organization on March 11, 2020. The lockdown and restriction policies that have been enacted to help prevent the spread of COVID-19 contradict the recommendations to ensure proper immunological development in children.

Data suggest that SARS-CoV-2 doesn’t represent a greater danger to children than the annual flu. Yet social interactions of children have been severely limited, including removing them from schools. Most of their extracurricular activities have been canceled and they have been discouraged from leaving their homes. Even the air they breathe is often filtered by masks and there is prevalent use of hand sanitizer.

Compromised Immunological Development

In short, most COVID-19 policies have maximized the potential for children to develop dysregulated immune systems. As a viral immunologist, I wasn’t overly concerned about this in the early stages of the pandemic when “temporary” measures were put in place to “flatten the curve.”

However, there is cause for concern one year later, after many places in Canada and other countries have spent months in lockdowns or with very limited social contact and activities to prevent the spread of COVID-19.

The youngest among us have had their immunological development compromised for one year and growing. The more immature the immune system is, the more prone it will be to becoming dysregulated during the pandemic.

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