Studies reveal vitamin D levels have a major impact on cancer risk.
There’s good news for those of you who have taken the proactive step to make sure you’re getting enough vitamin D. Several recent studies demonstrate vitamin D can significantly lower your cancer risk, both in terms of preventing cancer and in the treatment of cancer.
Vitamin D Reduces Cancer Mortality
In the first of these studies, 1 , 2 which included 25,871 patients, vitamin D supplementation was found to reduce the risk for metastatic cancer and death by 17 percent. The risk was reduced by as much as 38 percent among those who also maintained a healthy weight.
This was a really poorly done study as they only gave participants 2,000 IUs a day and never measured their blood levels. Had there been no improvement, I would not have been surprised, but the fact is it still reduced metastatic cancer and death by 17 percent, and they found significant benefit among those who were not obese.
This is pretty extraordinary but not as good as epidemiological studies that show a 50 percent to even 78 percent reduction in people who are vitamin D sufficient, as suggested in a study further below.
That said, UPI reported that vitamin D3’s ability to limit cancer severity and metastases, or the spread of cancer to other organs, was seen across all cancers and was more prominent among study participants who maintained healthy weight. : 3
Study co-author Dr. Paulette Chandler told UPI “The primary message [of our study] is that vitamin D may reduce the chance of developing metastatic or fatal cancer among adults without a diagnosis of cancer.”The study, published in JAMA Network Open, is a secondary analysis of the VITAL Study 4 which, in part, sought to determine whether taking 2,000 IUs of vitamin D per day would reduce the risk of cancer, heart disease or stroke in people who did not have a prior history of these diseases.
The VITAL study itself, which followed patients for an average of 5.3 years, found no statistical difference in overall cancer rates among those who took vitamin D3, but there was a reduction in cancer-related deaths, which is what prompted this secondary analysis.
Obesity May Inhibit Vitamin D’s Benefits
The fact that patients with a healthy weight derived a much greater benefit—a 38 percent reduced risk for metastatic cancer and death compared to 17 percent overall—suggests your body weight may play a significant role in whether vitamin D supplementation will provide you with the anticancer benefits you seek.
According to study co-author Dr. Paulette Chandler, assistant professor of medicine at Brigham and Women’s Hospital in Boston, “Our study highlights that obesity may confer resistance to vitamin D effects.” 5
There may be something to that. Research 6 published in 2010 found that dietary fructose inhibits intestinal calcium absorption, thereby inducing vitamin D insufficiency in people with chronic kidney disease.
That said, vitamin D tends to be lower in obese people in general, for the fact that it’s a fat-soluble nutrient and when you’re obese, the vitamin D ends up being “volumetrically diluted.” As explained in the paper “Vitamin D in Obesity,” published in 2017: 7
“Serum vitamin D is lower in obese people; it is important to understand the mechanism of this effect and whether it indicates clinically significant deficiency … Vitamin D is fat soluble, and distributed into fat, muscle, liver, and serum.
All of these compartments are increased in volume in obesity, so the lower vitamin D likely reflects a volumetric dilution effect and whole body stores of vitamin D may be adequate … Obese people need higher loading doses of vitamin D to achieve the same serum 25-hydroxyvitamin D as normal weight.”
While that particular paper stresses that lower vitamin D in obese individuals might not mean that they’re deficient, others disagree. For example, one study 8 , 9 found that for every 10 percent increase in body-mass index, there’s a 4.2 percent reduction in blood levels of vitamin D. According to the authors of that particular study, obesity may in fact be a causal factor in the development of vitamin D deficiency. 10
Vitamin D Also Improves Colorectal Cancer Outcomes
A scientific review 11 published in the September 2020 issue of the British Journal of Cancer noted that having low vitamin D is associated with poor colorectal cancer survival.
To assess whether vitamin D supplementation might improve survival in these patients, they reviewed the findings of seven trials, three of which included patients diagnosed with colorectal cancer from the outset and four population trials that reported survival in incident cases.
Overall, the meta-analysis found supplementation resulted in a 30 percent reduction in adverse colorectal cancer outcomes. Vitamin D also improved outcomes among patients already diagnosed with colorectal cancer.
According to the authors: 12 “Meta-analysis demonstrates a clinically meaningful benefit of vitamin D supplementation on [colorectal cancer] survival outcomes. Further well-designed, adequately powered RCTs are needed to … [determine] optimal dosing.”
Low Vitamin D Linked to Increased Cancer Incidence
Another review and meta-analysis, 13 this one published in November 2019 in Bioscience Reports, looked at vitamin D supplementation on cancer incidence and mortality in general. Ten randomized controlled trials with a pool of 81,362 participants were included in the analysis.
While the incidence rate of cancer was very similar between the vitamin D intervention group and the placebo control group (9.16 percent versus 9.29 percent), the risk reduction in mortality was deemed “significant.” As reported by the authors:
“The mortality rate of cancer was 2.11 percent (821 cases) and 2.43 percent (942 cases) in vitamin D intervention group and placebo group, respectively, resulting in a significant reduction in risk (RR = 0.87).
“There was no observable heterogeneity or publication bias … Our findings support a beneficial effect of vitamin D supplement on lowering cancer mortality, especially in subpopulations with no history of cancer, extra use of vitamin D, or calcium supplement.”
Vitamin D Protects Against Breast Cancer
Several studies have highlighted the benefit of vitamin D for breast cancer. For example, an analysis 14 by GrassrootsHealth published June 2018 in PLOS ONE showed women with a vitamin D level at or above 60 ng/mL (150 nmol/L) had an 82 percent lower risk of breast cancer compared to those with levels below 20 ng/mL (50 nmol/L).